A Study of Visual Evoked Potential for Functional Assessment of Visual Pathway in Ophthalmologically Normal Diabetes Mellitus Patients

Background and aim: Diabetic retinopathy(DR) is one of the most common complications of long-standing diabetes mellitus(DM).Early detection of this complication Apparel in the preclinical stages by Visual Evoked Potential (VEP) may help formulate management strategies to preserve Vision.With this background in mind, we conducted a cross-sectional s

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Decreased Mdm2 expression inhibits tumor development and extends survival independent of Arf and dependent on p53.

Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis.Arf controls Mdm2, which in turn regulates p53, but Arf and Mdm2 also have p53-independent functions that affect tumor development.Moreover, inhibition of oncogene-induced tumorigenesis relies on Arf and p53, but the requirements of Arf and p53 in tumor

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